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They are listed here as a reference for researchers investigating BPC-157

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831 Functionally upstream of UreG is UreE, and it is the UreG 2 -GTP form that productively engages Ni II -bound UreE 2 and accepts the metal, leading to dissociation of UreE following Ni II transfer (Figure 40B)

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It's an in-office procedure, typically done 1-3 times over several months

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